Our Approach //

We develop precision medicine tests and therapeutics

Pear Bio’s Cancer Model Generator

Pear Bio has developed the Cancer Model Generator, a modular process to create 3D cell culture models for each type of cancer and use live-cell imaging and 3D computer vision to predict treatment response to various treatment options

Personalized Testing

We create 3D cell cultures known as “immune-microtumors” to capture the human tumor microenvironment and test the efficacy of treatments

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Drug Discovery

Excess tissue is stored in our biobank for multi-omic analysis, and this feeds into our target and drug discovery pipeline

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For Personalized Medicine and Drug Discovery

Our Cancer Model Generator brings unprecedented insight into treatment options. Offering a flexible model for patients, oncologists and researchers.

Multiple Cancer Types

Pear Bio’s 3D immune-microtumors are developed for multiple types of solid tumors using the Cancer Model Generator process. This modular process includes the optimization of sample processing, hydrogel composition and growth medium composition for each cancer of interest.

Modality Agnostic

The relevant therapies for each cancer type, including combination therapies, can be tested. The system is modality agnostic, and we have validated small molecules, antibodies (including immunotherapies), antibody-drug conjugates, cell therapies and viral therapies.

Advanced 3D Cell Tracking System

A standardized pan-cancer cell tracking dye system, with the option to customize the system for specific projects.

Computer Vision Pipeline

A pan-cancer 3D computer vision pipeline analyzes complex cell behaviors over time using a combination of deep learning and traditional computer vision. Many dynamic behaviors, ranging from cell death to immune cell infiltration, cell migration and cell clustering/co-localization are measured to analyze treatment response.

Predictive Models

Predictive models are developed to predict patient response by correlating test results to actual patient outcomes through our clinical studies.

Read about our Clinical Trials

Multi-omic Analysis

The remaining tissue is cryopreserved and snap frozen. Cryopreserved samples can be thawed to test more therapies in the future. Snap frozen samples are used for multi-omic target discovery campaigns.

Read about our Drug Discovery Process

Are you a cancer patient?
Contact your oncologists to see if the Pear Bio test is appropriate for you

Personalized Testing Workflow

01/ Sample Collection

Fresh tissues are collected alongside whole-blood and patient data and shipped to Pear Bio’s central laboratories.

02/ Sample Preparation

A viable single cell suspension is isolated from patient tumor tissue and immune cells from blood. Different cell subpopulations are stained with fluorescent cell tracking dyes. The remaining unstained tissue is stored (cryopreserved and/or snap frozen) for future experiments, including multi-omic characterization.

03/ Microtumor Culture

3D immune-microtumors are created to capture the diverse cell types in the human tumor microenvironment.

04/ Drug Dosing

The relevant therapies for each cancer type, including combination therapies, are tested. The system works across drug modalities.

05/ Imaging

3D immune-microtumors are imaged daily, capturing cell responses at a single-cell resolution.

06/ Response Prediction

A pan-cancer computer vision pipeline analyzes complex cell behaviors over time using a combination of deep learning and traditional computer vision. Many dynamic behaviors ranging from cell death to immune cell infiltration are measured to analyze treatment response. A report is generated outlining the efficacy of each therapy on each patient’s sample.

Sample Collection

Sample Preparation

Microtumor Culture

Drug Dosing

Imaging

Response Prediction

See how we are bring personalized testing to patients

See how we are utilizing our approach and expertise in 3D cell culture systems to bring personalized testing to patients and oncologists.

Learn about Personalized Testing